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Exploris 240 Mass Spectrometer (Thermo Fisher Scientific)

Description

The Exploris 240 (Thermo Fisher Scientific) is a benchtop mass spectrometer featuring precursor ion selection using a high-performance quadrupole and detection via an Orbitrap Fourier transform analyzer. It provides high resolution, high mass accuracy, and high sensitivity.

From a technical perspective, two ion sources are available: an H-ESI II probe used for instrument calibration, and a nano-ESI source (Nanospray Flex) used in coupling with nano-HPLC.

Commissioned in February 2021.

Applications

  • Identification of low-abundance proteins in complex mixtures
  • Targeted quantification
  • Expression analysis with or without labeling in complex samples
  • Simultaneous identification and quantification in a single analysis
  • High-resolution MS/MS applications such as de novo sequencing and intact protein analysis

Requirements / Constraints

This instrument is not open access

Funding

This latest-generation equipment was funded with support from INRAE (€65k), BPMP and UAR BioCampus Montpellier (platform small equipment program 2019, €40k), and internal MSPP funds (€22k).

Additional co-funding was obtained from IBiSA (Platform call 2019, €90k) and the University of Montpellier (Research Support call 2020, €50k).

Site

MSPP

Exploris 240 (Thermo Fisher Scientific)